The sixth seed will next play Dutchman Botic van de Zandschulp, who ousted Roberto Bautista Agut in three sets.
The defending champion eliminated Swiss wild card Leandro Riedi 6-3, 6-2 to reach the second round. Based on his form Wednesday, the Canadian is keen to add another Swiss Indoors Basel trophy to his collection.
Felix Auger-Aliassime’s most recent title came in Basel one year ago.